I was told to mix at a rate up to 16 - 20 drops
per gallon. Also told not to use a surfactant. Finally, I was told that
it remains active in the plant for up to 6 weeks. The following is some
additional info I found on the net someplace.
You need to download to view these. You also need a PDF Reader like
Acrobat to view these.
www.download.com may be a good source for a PDF reader.
PDF downloadable file, 32kb Zephyr - another Trade name for Avid.
Hi, I've been having an email exchange with a concerned citizen who seems
to know something about avid, here's a
repost of that email exchange so far.
From: "Concerned Citizen"
Subject: Re: AVID
Date: Sat, 04 Dec 1999 16:10:08 PST
To: bcga@MauiMail.com
Concerned
> > Avid is not systemic, and is not readily absorbed by
> > plants, from soil....
Vic High
>Hey, thanks for the concern, sorry for not responding
>sooner. I followed that link you gave me, thanks for the
>thought. However, I had already cut and paste it's contents
>to my webpage previously.
>I guess I must be a little rusty on the terminology. I too
>am under the belief that avid won't work if applied to the
>soil. However, I'm under the impression that it is absorbed
>by the above ground plant tissues and remains effective in
>the plant tissues killing mites for 6-8 weeks. Is systemic
>the wrong word for this? If so, what would be a better term
>to use? I was going to suggest residual, but my
>understanding is that only those insects consuming the plant
>are affected. Those that only crawl on the plant are safe so
>long as they don't munch. Therefore, only the chimical
>absorbed into the plant tissue remains active for very long.
Concerned
I am not under the impression that avid is absorbed into the plant tissues
at all. I have done some tests
on plants treated with avid, and have not found that mites are killed
even 3 days later, but can spread, and infest plants
3 days later, in some cases.(Heavy light, good mite breeding conditions
like heat etc.) I think the 6-8 week thing is just
a factor of the life-cycle of the two-spotted mite, which can take
weeks to get a firm 'hold' on a garden, after initial
infestation. Avid seems to be a good way for people that cannot control
mites after infestation to get a good head start
on a crop, especially if the crop is only around for 8-10 weeks, after
the mites are killed. I have most definitally seen
crops 5-6 weeks after application that were seriously mited out. It
seems unlikely that a plant that was dipped with only
4-6 leaves or so sould possibly contain any measurable amount of abamectins
when it is 2-3 feet tall with over 1000
times the mass of the original plant, given the fast half-life of the
product. Don't know, but I do have some info coming
from Merck.
They were granted crop protection coverage in 1994 for some things...
------------------------
Crop Protection
Worldwide sales of abamectin-based products to protect various fruit, vegetable
and ornamental crops from
damage by mite and insect pests continue to grow. In the United States,
full registration was granted for strawberries,
tomatoes and lettuce. Claims for citrus were expanded to include leafminers.
-------------------------
The avermectins, which have been refined by Merck, which are the group
which avid comes from, are used to
treat many things, and are anti-parasitic, and pesticidal, and even
used on HUMANS!, (I think there are 8 avermectins)
Here is another excerpt from Merck's site.
--------------------------
Few examples better illustrate our approach to research and development
than the process that began with a soil
culture provided by the Kitasato Institute in Japan.
From that single sample - and the combined efforts of hundreds of
Merck scientists - flowed what one Merck
researcher called an "incredible discovery - a microorganism that produced
a fabulous family of substances with unprecedented
potency and activity against both internal and external parasites of
animals, as well as pests that destroy crops."
Analysis of the culture found eight distinct, but chemically related, active
compounds that Merck chemists dubbed
the avermectins. One pair of these avermectins, which was chemically
modified, demonstrated extraordinary activity against a
broad spectrum of animal parasites. Named dihydroavermectin B, it has
emerged as a true breakthrough in animal health - with
formulations available today for use in cattle, sheep, horses, swine,
and dogs.
Perhaps the most satisfying use for dihydroavermectin B, however, has been
in human health, where it is used to
prevent onchocerciasis, or river blindness - a leading cause of blindness
in developing Third World countries. Untreated, it can
cause permanent eye damage, even blindness. However, a single dose
of dihydroavermectin B every 12 months is sufficient to
block development of the parasite to the mature form, which releases
the disease-causing microfilariae.
Vic High
This is getting interesting, thanks for the info at the bottom ;) My experience
has been very different than yours. When
I first started using Avid, I was gardening perpetual harvest style,
where I would harvest a portion of the garden every 2 weeks.
And I was loosing the mite war. I sprayed my veg room and all plants
newly being placed into the flower room. But I didn't spray
any plants already in the flower room out of health concerns for the
consumers. The untreated crop was growing right next to the
treated crop, but the treated crop remained mite free for about 6 weeks
before mites started migrating. The second application
completely erradicated the mite population in the veg room, but it
took about 3-4 months before I was able to completely clean them
out of the flower room, since I wouldn't spray a flowering plant. Everytime
I introduced new plants to the flowering room, I would
spray them.
However, one important note is that I have no certainty that what I was
using was in fact Avid. I purchased it black
market and it came in a small unmarked bottle. So maybe it is something
else and all us in this industry are just being misinformed that
it is indeed Avid. Who knows, I should see if I can get my hands on
some legit avid and compare ;)
Oh hey, in your references of crop plants, have you seen any mention
of the tobacco industry? I figure they would have the real info that
would be most relevent to our needs, hehe.
Anyway, thanks again, Vic
I thought this might be on interest. Avid is a serious chemical and should
be used with
caution. However, it doesn't look as toxic as some people say. I saw some
posts on
Weedbase that say it is not aproved for food crops....doesn't look like
that is the case
as it is approved for citrus, pears, and nuts. Do take precautions if you
use it
(protective clothing and respirator) and don't flower out clones that have
been sprayed
with it....take new clones instead.
E X T O X N E T
Extension Toxicology Network
Pesticide Information Profiles
A Pesticide Information Project of Cooperative Extension Offices of Cornell
University, Oregon State University, the University of Idaho, and the
University of California at Davis and the Institute for Environmental
Toxicology, Michigan State University. Major support and funding was
provided by the USDA/Extension Service/National Agricultural Pesticide
Impact Assessment Program.
EXTOXNET primary files maintained and archived at Oregon State University
Revised June 1996
------------------------------------------------------------------------
Abamectin
------------------------------------------------------------------------
Trade and Other Names: Abamectin is also known as Avermectin B1a. Trade
names include Affirm, Agri-Mek, Avermectin, Avid, MK 936, Vertimec, and
Zephyr.
Regulatory Status: Abamectin is a General Use Pesticide (GUP). It is
classified as toxicity class IV - practically nontoxic, and has no
precautionary statement on its label.
Chemical Class: antibiotic
Introduction: Abamectin is a mixture of avermectins containing about 80%
avermectin B1a and 20% avermectin B1b. These two components, B1a and B1b,
have very similar biological and toxicological properties. The avermectins
are antibiotic compounds derived from the soil bacterium Streptomyces
avermitilis. Abamectin is a natural fermentation product of this bacterium.
It acts as an insecticide by affecting the nervous system of and paralyzing
insects. Abamectin is used to control insect and mite pests of citrus,
pear, and nut tree crops, and it is used by homeowners for control of fire
ants.
Formulation: Not Available
Toxicological Effects:
* Acute toxicity: Abamectin is highly toxic to insects and may be highly
toxic to mammals as well [141]. Emulsifiable concentrate formulations
may cause slight to moderate eye irritation and mild skin irritation
[8]. Symptoms of poisoning observed in laboratory animals include
pupil dilation, vomiting, convulsions and/or tremors, and coma
[141,142]. Abamectin acts on insects by interfering with the nervous
system. At very high doses, it can affect mammals, causing symptoms of
nervous system depression such as incoordination, tremors, lethargy,
excitation, and pupil dilation. Very high doses have caused death from
respiratory failure [143]. Abamectin is not readily absorbed through
skin. Tests with monkeys show that less than 1% of dermally applied
abamectin was absorbed into the bloodstream through the skin [141].
Abamectin does not cause allergic skin reactions [142]. The oral LD50
for abamectin in rats is 10 mg/kg, and in mice ranges from 14 mg/kg to
greater than 80 mg/kg [141,142]. The oral LD50 for the product Avid EC
in rats is 650 mg/kg [8]. The dermal LD50 for technical abamectin in
rats and rabbits is greater than 330 mg/kg [144].
* Chronic toxicity: In a 1-year study with dogs given oral doses of
abamectin, dogs at the 0.5 and 1 mg/kg/day doses exhibited pupil
dilation, weight loss, lethargy, tremors, and recumbency [141].
Similar results were seen in a 2-year study with rats fed 0.75, 1.5,
or 2 mg/kg/day. Rats at all the dosage levels exhibited body weight
gains significantly higher than the controls. A few individuals in the
high dose group exhibited tremors [141]. When mice were fed 8
mg/kg/day for 94 weeks, the males developed dermatitis and changes in
blood formation in the spleen, while females exhibited tremors and
weight loss [142].
* Reproductive effects: Rats given 0.40 mg/kg/day of abamectin had
increased stillbirths, decreased pup viability, decreased lactation,
and decreased pup weights [142]. These data suggest that abamectin may
have the protential to cause reproductive effects at high enough
doses.
* Teratogenic effects: Abamectin produced cleft palate in the offspring
of treated mice and rabbits, but only at doses that were also toxic to
the mothers [141]. There were no birth defects in the offspring of
rats given up to 1 mg/kg/day [142]. Abamectin is unlikely to cause
teratogenic effects except at doses toxic to the mother.
* Mutagenic effects: Abamectin does not appear to be mutagenic.
Mutagenicity tests in live rats and mice were negative. Abamectin was
shown to be nonmutagenic in the Ames test [1].
* Carcinogenic effects: Abamectin is not carcinogenic in rats or mice.
The rats were fed dietary doses of up to 2 mg/kg/day for 24 months,
and the mice were up to 8 mg/kg/day for 22 months [141]. These
represent the maximum tolerated doses.
* Organ toxicity: Animal studies indicate that abamectin may affect the
nervous system.
* Fate in humans and animals: Tests with laboratory animals show that
ingested avermectin B1a is not readily absorbed into the bloodstream
by mammals and that it is rapidly eliminated from the body within 2
days via the feces [142]. Rats given single oral doses of avermectin
B1a excreted 69 to 82% of the dose unchanged in the feces. The average
half-life of avermectin B1a in rat tissue is 1.2 days [144]. Lactating
goats given daily oral doses for 10 days excreted 89% of the
administered avermectin, mainly in the feces. Less than 1% was
recovered in the urine [144].
Ecological Effects:
* Effects on birds: Abamectin is practically nontoxic to birds [142].
The LD50 for abamectin in bobwhite quail is >2000 mg/kg. The dietary
LC50 is 3102 ppm in bobwhite quail [145]. There were no adverse
effects on reproduction when mallard ducks were fed dietary doses of
3, 6, or 12 ppm for 18 weeks [145].
* Effects on aquatic organisms: Abamectin is highly toxic to fish and
extremely toxic to aquatic invertebrates [142]. Its LC50 (96-hour) is
0.003 mg/L in rainbow trout, 0.0096 mg/L in bluegill sunfish, 0.015
mg/L in sheepshead minnows, 0.024 mg/L in channel catfish, and 0.042
mg/L in carp. Its 48-hour LC50 in Daphnia magna, a small freshwater
crustacean, is 0.003 mg/L. The 96-hour LC50 for abamectin is 0.0016
mg/L in pink shrimp, 430 mg/L in eastern oysters, and 153 mg/L in blue
crab [145]. While highly toxic to aquatic organisms, actual
concentrations of abamectin in surface waters adjacent to treated
areas are expected to be low. Abamectin did not bioaccumulate in
bluegill sunfish exposed to 0.099 ug/L for 28 days in a flow-through
tank. The levels in fish were from 52 to 69 times the ambient water
concentration, indicating that abamectin does not accumulate or
persist in fish [145].
* Effects on other organisms: Abamectin is highly toxic to bees, with a
24-hour contact LC50 of 0.002 ug/bee and an oral LD50 of 0.009 ug/bee
[145].
Environmental Fate:
* Breakdown in soil and groundwater: Abamectin is rapidly degraded in
soil. At the soil surface, it is subject to rapid photodegradation,
with half-lives of 8 hours to 1 day reported [142,145]. When applied
to the soil surface and not shaded, its soil half-life is about 1
week. Under dark, aerobic conditions, the soil half-life was 2 weeks
to 2 months [142]. Loss of abamectin from soils is thought to be due
to microbial degradation. The rate of degradation was significantly
decreased under anaerobic conditions [145]. Because abamectin is
nearly insoluble in water and has a strong tendency to bind to soil
particles, it is immobile in soil and unlikely to leach or contaminate
groundwater [145]. Compounds produced by the degradation of abamectin
are also immobile and unlikely to contaminate groundwater [145].
* Breakdown in water: Abamectin is rapidly degraded in water. After
initial distribution, its half-life in artificial pond water was 4
days. Its half-life in pond sediment was 2 to 4 weeks [145]. It
undergoes rapid photodegradation, with a half-life of 12 hours in
water [142]. When tested at pH levels common to surface and
groundwater (pH 5, 7, and 9), abamectin did not hydrolyze [145].
* Breakdown in vegetation: Plants do not absorb abamectin from the soil
[145]. Abamectin is subject to rapid degradation when present as a
thin film, as on treated leaf surfaces. Under laboratory conditions
and in the presence of light, its half-life as a thin film was 4 to 6
hours [145].
Physical Properties:
* Appearance: Abamectin is a colorless to yellowish crystalline powder
[1].
* Chemical Name: avermectin B1
* CAS Number: 71751-41-2 (avermectin B1a and avermectin B1b) [1]
* Molecular Weight: 873.11
* Water Solubility: Insoluble [1]
* Solubility in Other Solvents: v.s. in acetone, methanol, toluene,
chloroform, and ethanol [1]
* Melting Point: 150-155 C [1]
* Vapor Pressure: Negligible [1]
* Partition Coefficient: Not Available
* Adsorption Coefficient: 5000 (estimated) [53]
Exposure Guidelines:
* ADI: 0.0001 mg/kg/day [12]
* MCL: Not Available
* RfD: 0.0004 mg/kg/day [13]
* PEL: Not Available
* HA: Not Available
* TLV: Not Available
Basic Manufacturer:
Merck Agvet
Division of Merck and Co., Inc.
P.O. Box 2000
Rahway, NJ 07065
* Phone: 908-855-4277
* Emergency: Not Available
References:
References for the information in this PIP can be found in Reference List
Number 10
------------------------------------------------------------------------
DISCLAIMER: The information in this profile does not in any way replace
or
supersede the information on the pesticide product labeling or other
regulatory requirements. Please refer to the pesticide product labeling.
-------------------- MATERIAL SAFETY DATA SHEET -------------------
Agri-Mek 0.15 Emulsifiable Concentrate
MERCK AGVET DIVISION/MERCK & CO., INC.
-----------------------------------------------------------
MANUFACTURER: MERCK AGVET DIVISION
P.O. BOX 2000,
RAHWAY, NJ 07065
PRODUCT NAME: AGRI-MEK 0.15 EMULSIFIABLE CONCENTRATE
PLANT MSDS CODE: AG-056
EMERGENCY TELEPHONE NUMBERS:
1-800-672-6372 - Human Health Adverse Experience
1-800-325-2577 - Animal Health Adverse Experience
-----------------------------------------------------------
SECTION 1 - MATERIAL IDENTIFICATION
-----------------------------------------------------------
CHEMICAL NAME: Abamectin is a mixture of Avermectins
containing primarily Avermectin B1a.
TRADE NAME: Agri-Mek 0.15 Emulsifiable Concentrate
SYNONYMS: Avermectin B1 Solution
MERCK ID CODE: 06432A
CHEMICAL CLASSIFICATION: Avermectins
INTENDED USE: Agricultural insecticide-miticide
-----------------------------------------------------------
SECTION 2 - PRINCIPAL HAZARDOUS
COMPONENT(S)
-----------------------------------------------------------
COMPONENT/
MOLECULAR MOLECULAR
CAS NUMBER
FORMULA WEIGHT
PERCENT (%)
-----------------------------------------------------------
Abamectin
1.9
B1a/71751-41-2 C48H72O14
873.08
B1b/Mixture
C47H70O14 859.05
Proprietary
Ingredient(s)/
Not avail.
Not avail. Not avail. 98.1
-----------------------------------------------------------
SECTION 3 - PHYSICAL PROPERTY DATA
-----------------------------------------------------------
APPEARANCE: Clean, clear, straw to rust colored liquid
ODOR/THRESHOLD LEVEL (ppm): Do not test for odor to avoid
breathing vapors.
BOILING POINT (deg C/deg F): Not established
FREEZING POINT (deg C/deg F): Not available
MELTING RANGE (deg C/deg F): Not applicable
pH: (1:9 aqueous dilution) 2.6-3.6
SOLUBILITY IN WATER: Not established
SPECIFIC GRAVITY (Water = 1): 0.96
VAPOR DENSITY (Air = 1): Greater than 1
VAPOR PRESSURE (mm Hg @ deg C/deg F): Not applicable
VOLATILE COMPONENTS (% w/w): 56%
-----------------------------------------------------------
SECTION 4 - FIRE AND EXPLOSION
HAZARD DATA
-----------------------------------------------------------
FLASH POINT (deg C/deg F): 72 deg C/161 deg F
FLASH POINT TEST METHOD: Setaflash closed cup
AUTOIGNITION TEMPERATURE (deg C/deg F): Not available
FLAMMABLE LIMITS:
LEL (%): Not applicable
UEL (%): Not applicable
EXTINGUISHING MEDIA: Use dry chemical, foam or CO2
SPECIAL FIRE FIGHTING PROCEDURES: Excessive use of water
may create contaminated run-off water which may cause
further contamination. Follow environmental and personal
safety precautions noted for spill or leak. Wear self-
contained breathing apparatus and full protective
clothing. Move container from fire area if you can do it
without risk. Keep upwind and evacuate personnel in the
immediate area. Follow post-fire decontamination
procedures including thorough washing of all fire
fighting clothing and equipment. Fire fighters must
thoroughly wash immediately following incident.
FIRE AND EXPLOSION HAZARDS: Agri-Mek is a combustible
emulsifiable concentrate liquid.
HAZARDOUS DECOMPOSITION PRODUCTS RESULTING FROM A FIRE:
Toxic gases including carbon monoxide and carbon dioxide
and smoke can be generated.
-----------------------------------------------------------
SECTION 5 - REACTIVITY DATA
-----------------------------------------------------------
STABILITY: Stable under normal conditions.
STORAGE CONDITIONS TO AVOID: None
INCOMPATIBILITIES: None
HAZARDOUS POLYMERIZATION: None
-----------------------------------------------------------
SECTION 6 - EMERGENCY AND FIRST AID
PROCEDURES
-----------------------------------------------------------
EYE CONTACT: Flush with plenty of water for at least 15
minutes. Get medical attention.
SKIN CONTACT: Wash with copious amounts of water and soap.
Remove contaminated clothing.
INHALATION: Remove from contaminated area immediately. Get
immediate medical attention.
INGESTION: Get immediate medical attention. Induction of
vomiting as directed by a physician depending on the
quantity ingested.
MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE: None known
-----------------------------------------------------------
SECTION 7 - HEALTH HAZARD DATA
-----------------------------------------------------------
OSHA
ACGIH-1991-92
PERMISSIBLE THRESHOLD
MERCK EXPOSURE
EXPOSURE LIMIT LIMIT VALUE CONTROL LIMIT
COMPONENT (PEL)
(TLV) (ECL)
-----------------------------------------------------------
Abamectin Not
Not 0.04
mg/M(3)
established established
CARCINOGEN DESIGNATION: Not listed as a carcinogen with
NTP, OSHA, or IARC.
-----------------------------------------------------------
QUANTITATIVE TOXICITY DATA: Formulation
TEST SPECIES
ROUTE
RESULT
-----------------------------------------------------------
LD50 Rat
Oral
300 mg/kg (0.312
ml/kg-Equivalent to
6.8 mg/kg of the
active ingredient)
LD50 Rabbit
Dermal
Greater than 1.8
gm/kg
LC50 Rats
Inhalation 3.5 mg/L (4 hr nose
only)
Skin Guinea Pig Intradermal/
Skin sensitizer
Sensitization Dermal
(Positive response
in 10/11 animals)
-----------------------------------------------------------
EFFECTS OF ACUTE EXPOSURE:
EYE CONTACT: Moderate ocular irritant.
SKIN CONTACT: The emulsifiable concentrate was shown to
be a sensitizer in the guinea pig maximization test.
Prolonged or frequently repeated exposure may cause
allergic skin reactions in some individuals.
INHALATION: Moderately toxic if inhaled. Avoid inhaling
spray mist.
INGESTION: Moderately toxic orally in animal studies.
EFFECTS OF CHRONIC EXPOSURE: Chronic toxicity studies on
the formulated compound have not been performed.
Technical grade Abamectin has been studied extensively.
In 12 week studies in dogs mydriasis and weight loss were
seen in animals given doses above 1.0 mg/kg/day. No
evidence of carcinogenicity has been seen in chronic
feeding studies in rats and mice.
-----------------------------------------------------------
SECTION 8 - SPILL/LEAK/DISPOSAL
PROCEDURE
-----------------------------------------------------------
STEPS TO BE TAKEN IN CASE MATERIALS ARE RELEASED: Contact
emergency response personnel. Keep unnecessary persons
away. If emergency response personnel are unavailable,
absorb small spills on spill pillows or other suitable
absorbing material and place in a sealed container for
disposal. Dike large spills and transfer to an
appropriate container for disposal. Use suitable
protective equipment (Section 9). Follow all fire
prevention procedures (Section 4).
Abamectin is very toxic to certain aquatic species. Avoid
contact of spilled materials and runoff with soil and
surface waterways. Residual surface material should be
removed with towels moistened with methanol.
Incinerate all spill material and residues at
temperatures greater than 600 deg C.
ENVIRONMENTAL DATA: Pure Abamectin: LC50 (Daphnia Magna) 48
hours = 0.34 ppb (very highly toxic to aquatic
organisms).
This product is highly toxic to bees.
For additional assistance, CHEMTREC provides a toll-free
Hotline for chemical emergencies regarding spills, leaks,
exposure or accidents: 1-800-424-9300.
-----------------------------------------------------------
SECTION 9 - SPECIAL PROTECTION
INFORMATION
-----------------------------------------------------------
RESPIRATORY: If use results in vapor/mist concentrations
above the ECL, an approved respirator for vapors/mists is
recommended.
HANDS/ARMS: Rubber gloves should be worn. Wash thoroughly
with soap and water after handling.
EYE/FACE: To protect against accidental eye contact,
goggles should be worn.
ADDITIONAL PROTECTIVE EQUIPMENT: Protective clothing such
as coveralls and/or apron and rubber boots. Wash
protective clothing after use.
VENTILATION: Proper ventilation should be maintained at all
times to prevent high vapor/mist conditions. Use only in
well ventilated areas or outdoors.
-----------------------------------------------------------
SECTION 10 - SPECIAL PRECAUTIONS
-----------------------------------------------------------
PRECAUTIONS TO BE TAKEN WHEN:
HANDLING AND STORING, ETC.: Store in tightly closed
container in a cool, dry, well ventilated location.
Do
not store near heat or flame. Do not reuse empty
container.
OTHER: May be harmful if inhaled. Do not breathe spray
mist. Harmful if swallowed or absorbed through skin.
Avoid contact with eyes, skin or clothing. Wash
thoroughly with soap and water after handling. Keep
out
of the reach of children.
-----------------------------------------------------------
SECTION 11 - BASIC TRANSPORTATION
DESCRIPTION
-----------------------------------------------------------
U.S. DOT: Pesticides, Liquid, Toxic, N.O.S., (Abamectin
Solution), 6.1, UN2902, PG III
ICAO/IATA: Pesticides, Liquid, Toxic, N.O.S. (Abamectin
Solution), 6.1, UN2902, III
IMO: Pesticides, Liquid, Toxic, N.O.S. (Abamectin
Solution), IMO Class 6.1, UN2902 (Packing Group III)
-----------------------------------------------------------
SECTION 12 - MSDS PREPARATION
-----------------------------------------------------------
Revision 2, October 1991, L. Grosso.....
Revision 3, January 1992, E. Sargent
Revision 4, June 1992, F. Lewandowski
Revision 5, May 1993, R. Dybas
Revision 6, February 1995, P. Griffin
Revision 7, April 1995, M. Waters
E.V. Sargent, Ph.D.
Corporate Safety & Industrial Hygiene
DATE: April 15, 1991
F.J. Lewandowski, Jr.
Merck AgVet
DATE: April 15, 1991
-----------------------------------------------------------
While the information set forth is believed to be accurate
as of the date hereof, Merck AgVet makes no warranty with
respect hereto and disclaims all liability from reliance
thereon.
-----------------------------------------------------------
DISCLAIMER OF EXPRESSED AND IMPLIED WARRANTIES: although
preparer and owner have taken reasonable
care in the
preparation of this document, we extend no warranties and
make no representation as to the accuracy or completeness
of the information contained herein,
and assume no
responsibility regarding the
suitability of this
information for the user's intended purposes or for
the
consequences of its use. Each
user should make a
determination as to the suitability of the information for
their particular purpose(s). A request has been made to the
manufacturer to approve the contents of
this material
safety data sheet. Upon receipt of any changes a new MSDS
will be made available.
-----------------------------------------------------------
COMPAS Code: 11400403
NAC Approved Date: / / .
-----------------------------------------------------------
*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER
: CL1203000
CHEMICAL NAME
: Avermectin B(sub 1)
CAS REGISTRY NUMBER : 71751-41-2
OTHER CAS REGISTRY NOS. : 86753-29-9
LAST UPDATED
: 199409
DATA ITEMS CITED : 8
COMPOUND DESCRIPTOR : Agricultural Chemical
SYNONYMS/TRADE NAMES :
* Abamectin
* Affirm
* Agrimek
* AVID EC
* Avomec
* MK 936
* Vertimec
* Zephyr
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent
- rat
DOSE/DURATION
: 10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal
dose value
REFERENCE :
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs,
and Biologicals",
11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989
Volume(issue)/page/year:
11,3,1989
TYPE OF TEST
: LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent
- rat
DOSE/DURATION
: 1100 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal
dose value
REFERENCE :
DEVEAA Defense des Vegetaux. (Federation Nationale des
Groupements de
Protection des Cultures, 149, rue de Bercy, 75595 Paris
Cedex, 12, France)
V.1- 1947- Volume(issue)/page/year: 42(249-250),41,1988
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent
- mouse
DOSE/DURATION
: 13600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal
dose value
REFERENCE :
DEVEAA Defense des Vegetaux. (Federation Nationale des
Groupements de
Protection des Cultures, 149, rue de Bercy, 75595 Paris
Cedex, 12, France)
V.1- 1947- Volume(issue)/page/year: 42(249-250),41,1988
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intracerebral
SPECIES OBSERVED : Rodent
- mouse
DOSE/DURATION
: 1740 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub.
B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977-
Volume(issue)/page/year: 60,289,1992
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Primate
- monkey
DOSE/DURATION
: 17 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal
dose value
REFERENCE :
DEVEAA Defense des Vegetaux. (Federation Nationale des
Groupements de
Protection des Cultures, 149, rue de Bercy, 75595 Paris
Cedex, 12, France)
V.1- 1947- Volume(issue)/page/year: 42(249-250),41,1988
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration
onto the skin
SPECIES OBSERVED : Rodent
- rabbit
DOSE/DURATION
: >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal
dose value
REFERENCE :
DEVEAA Defense des Vegetaux. (Federation Nationale des
Groupements de
Protection des Cultures, 149, rue de Bercy, 75595 Paris
Cedex, 12, France)
V.1- 1947- Volume(issue)/page/year: 42(249-250),41,1988
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Bird -
duck
DOSE/DURATION
: 84600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal
dose value
REFERENCE :
DEVEAA Defense des Vegetaux. (Federation Nationale des
Groupements de
Protection des Cultures, 149, rue de Bercy, 75595 Paris
Cedex, 12, France)
V.1- 1947- Volume(issue)/page/year: 42(249-250),41,1988
TYPE OF TEST
: LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Bird -
domestic
DOSE/DURATION
: >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal
dose value
REFERENCE :
DEVEAA Defense des Vegetaux. (Federation Nationale des
Groupements de
Protection des Cultures, 149, rue de Bercy, 75595 Paris
Cedex, 12, France)
V.1- 1947- Volume(issue)/page/year: 42(249-250),41,1988
*** END OF RECORD ***